Methods in Cell Biology Vol.35 Functional Organization of the Nucleus A Laboratory Guide

A text intended for researchers and students in cell biology, genetics and molecular biology, developmental biology, biochemistry and biophysics. The complex problem of the relationship between nuclear structure and function demands a multidisciplinary, multifaceted approach. This laboratory guide is designed for researchers, from graduate students to professors, who need detailed protocols and general discussions on a broad range of techniques. The volume presents a selection of different methodological approaches for the analysis of nuclear structure and function - from cytological to molecular to genetic. These include visualization of nucleic acid sequences using hybridization probes, visualization of proteins using immunological probes, isolation of chromatin fractions, mapping "in vitro" protein-DNA interactions, reconstitution of functional templates and nuclear substructures, and genetic approaches to identifying and characterizing chromosomal components.

• Series: Methods in Cell Biology
• Hardcover: 590 pages
• Publisher: Academic Press
• Language: English
• ISBN-10: 0125641354
• ISBN-13: 978-0125641357
• Product Dimensions: 9 x 6 x 1 inches

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