Methods in Enzymology Vol.132 Immunochemical Techniques, Part J: Phagocytosis and Cell-Mediated

This chapter provides an overview of phagocytosis. Phagocytosis is regarded as the most important defense mechanism in all phyla of the animal kingdom. Among protozoa, phagocytosis is not only the means of defense against foreign cells and particles but also the principal mode of ingesting food. The ultimate disposal of all infectious agents and other unwanted particles, which have been detected and processed with the help of other branches of the immune system, occurs through phagocytosis so that phagocytosis represents the final and most indispensable step in immunological defense system. Professional and nonprofessional phagocytes are demarcated according to (1) whether or not the cells principal known function is phagocytic and (2) whether the cells can digest as well as ingest particles. The various phagocytic mononuclear leukocytes that used to be taken to inhabit the reticuloendothelial system have been grouped together as the mononuclear phagocytes. Mononuclear phagocytes comprise the promonocytes in the bone marrow that give rise to the circulating monocytes, which ultimately mature into the mobile or fixed macrophages, found in tissues, such as bone marrow, bone tissue, spleen, and nervous system.

• Series: Methods in Enzymology (Book 132)
• Hardcover: 717 pages
• Publisher: Academic Press; 1 edition (January 11, 1987)
• Language: English
• ISBN-10: 0121820327
• ISBN-13: 978-0121820329
• Product Dimensions: 6.1 x 1.6 x 9.2 inches

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