Methods in Enzymology Vol.142 Metabolism of Aromatic Amino Acids and Amines

The monooxygenase, phenylalanine 4-monooxygenase (hydroxylase) (EC 1.14.16.1), catalyzes the irreversible conversion of phenylalanine to tyrosine. In mammals, the reaction is generally recognized as the ratelimiting step in the complete atabolism of phenylalanine to CO2 and water.~ The enzyme shows an absolute requirement for an unconjugated pterin ("pterin" is the trivial name for a 2-amino-4-hydroxypteridine). This requirement can be filled by the naturally occurring pterin, tetrahydrobiopterin, 2 whose structure is shown in Fig. 1, or by several synthetic tetrahydropterins, such as 6-methyltetrahydropterin or 6,7-dimethyltetrahydropterin.

• Hardcover: 732 pages
• Publisher: Academic Press;
  
• Language: English
• ISBN-10: 0121820424
• ISBN-13: 978-0121820428
• Product Dimensions: 6.1 x 1.6 x 9.2 inches

Link Download
http://nitroflare.com/view/02E2FF1652DAC0F
https://drive.google.com/drive/folders/1yLBzZ1rSQoNjmWeJTZ3WGQHg04L1