Methods in Enzymology Vol.252 Biothiols, Part B: Glutathione and Thioredoxin

This chapter focuses on the absorption and tissue distribution of Glutathione (GSH) distribution in natural products. GSH is present in most plant and animal tissues from which the human diet is derived. Much of this GSH is bioavailable because cells of the gastrointestinal tract have Na+-dependent and Na+-independent uptake mechanisms, and net absorption of GSH from the lumen into the vascular circulation occurs in the small intestine. In addition, GSH can function as an antioxidant in the ingesta, can maintain ascorbate in a reduced and functional form, can directly react with and inactivate toxic electrophiles in the diet, and can be broken down to yield cysteine. Studies have shown that dietary GSH enhances metabolic clearance of dietary peroxidized lipids and decreases their net absorption and that consumption of foods high in GSH content is associated with about a 50% reduction in risk of oral and pharyngeal cancer. Glutathione is readily oxidized by food processing and preparation, and many foods contain reactive electrophilic compounds that can remove GSH even after food is ingested. Although knowledge of GSH contents of foods remains incomplete, studies have provided insight into the range of values and provide some useful generalizations.

• Series: Methods in Enzymology (Book 252)
• Hardcover: 382 pages
• Publisher: Academic Press;
  
• Language: English
• ISBN-10: 0121821536
• ISBN-13: 978-0121821531
• Product Dimensions: 0.8 x 6.5 x 9.5 inches

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