This chapter introduces two new phototriggers for caging nucleotides, amino acids, peptides, and related functional group derivatives, potentially including higher-order homologs. These new phototriggers have several advantages that favor them over the conventional o-nitrobenzyl derivatives, including a more rapid release of the substrate by a primary photochemical fragmentation process; adequate to excellent aqueous solubility; and stable, benign photoproducts. Added attractive features for the p-hydroxyphenacyl phototrigger include its rearrangement to a phenylacetic acid, thus shifting the chromophore absorption to a shorter wavelength, eliminating its interference with the incident radiation. Finally, the absence of a chiral center eliminates diastereomeric mixtures during synthesis. Series: Methods in Enzymology (Book 291) Hardcover: 529 pages Publisher: Academic Press Language: English ISBN-10: 0121821927 ISBN-13: 978-0121821920 Product Dimensions: 6 x 1.2 x 9 inches Link Download http://nitroflare.com/view/018EC174E027544https://drive.google.com/drive/folders/1yLBzZ1rSQoNjmWeJTZ3WGQHg04L1
