Methods in Enzymology Vol.291 Caged Compounds

Discussion in 'Methods in Enzymology Book Series' started by kl915286, Aug 2, 2016.

  1. kl915286

    kl915286 New Member

    [​IMG]
    This chapter introduces two new phototriggers for caging nucleotides, amino acids, peptides, and related functional group derivatives, potentially including higher-order homologs. These new phototriggers have several advantages that favor them over the conventional o-nitrobenzyl derivatives, including a more rapid release of the substrate by a primary photochemical fragmentation process; adequate to excellent aqueous solubility; and stable, benign photoproducts. Added attractive features for the p-hydroxyphenacyl phototrigger include its rearrangement to a phenylacetic acid, thus shifting the chromophore absorption to a shorter wavelength, eliminating its interference with the incident radiation. Finally, the absence of a chiral center eliminates diastereomeric mixtures during synthesis.
    • Series: Methods in Enzymology (Book 291)
    • Hardcover: 529 pages
    • Publisher: Academic Press
    • Language: English
    • ISBN-10: 0121821927
    • ISBN-13: 978-0121821920
    • Product Dimensions: 6 x 1.2 x 9 inches
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