Methods in Enzymology Vol.291 Caged Compounds

Discussion in 'Methods in Enzymology Book Series' started by kl915286, Aug 2, 2016.

  1. kl915286

    kl915286 New Member

    This chapter introduces two new phototriggers for caging nucleotides, amino acids, peptides, and related functional group derivatives, potentially including higher-order homologs. These new phototriggers have several advantages that favor them over the conventional o-nitrobenzyl derivatives, including a more rapid release of the substrate by a primary photochemical fragmentation process; adequate to excellent aqueous solubility; and stable, benign photoproducts. Added attractive features for the p-hydroxyphenacyl phototrigger include its rearrangement to a phenylacetic acid, thus shifting the chromophore absorption to a shorter wavelength, eliminating its interference with the incident radiation. Finally, the absence of a chiral center eliminates diastereomeric mixtures during synthesis.
    • Series: Methods in Enzymology (Book 291)
    • Hardcover: 529 pages
    • Publisher: Academic Press
    • Language: English
    • ISBN-10: 0121821927
    • ISBN-13: 978-0121821920
    • Product Dimensions: 6 x 1.2 x 9 inches
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    Last edited by a moderator: Nov 29, 2021

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