Methods in Enzymology Vol.357 Cytochrome P450, Part C

Data from P450 protein sequences may be derived are growing at a pace that is faster than it can be effectively searched. The process of systematically finding and assembling all P450 sequences for a given species is slow and tedious. The P450 family has reached complete status in several eukaryotic species. Results from Arabidopsis, Dictyostelium, and three animals suggest that the evolutionary history of P450s in the crown group of eukaryotes is largely independent. The main lines starting from a billion or more years ago have been diverging from very few (two or three) P450 genes shared in the crown group common ancestor. The finding that diatoms have a CYP97 in common with plants points to CYP51 and CYP97 being in the last ancestor of plants and Stramenopiles. CYP524 in Dictyostelium may have a common ancestor with CYP710 in plants. Aside from these similarities across kingdoms, most P450s in different kingdoms seem to be derived independently. More complete data sets will clarify this and identify the precursor P450s present in the earliest eukaryotes. Deeper sampling of animals such as the sea urchin, Ciona intestinalis—the most primitive creature known with a notochord—proposed by the Department of Energy, a radial animal like a jellyfish, and a sponge would make the evolutionary history of P450s in animals apparent.

• Series: Methods in Enzymology (Book 357)
• Hardcover: 421 pages
• Publisher: Academic Press;
• Language: English
• ISBN-10: 0121822605
• ISBN-13: 978-0121822606
• Product Dimensions: 0.8 x 6.5 x 9.5 inches

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