Methods in Enzymology Vol.406 Regulators and Effectors of Small GTPases: Rho Family

The Ras superfamily (>150 human members) encompasses Ras GTPases involved in cell proliferation, Rho GTPases involved in regulating the cytoskeleton, Rab GTPases involved in membrane targeting/fusion and a group of GTPases including Sar1, Arf, Arl and dynamin involved in vesicle budding/fission. These GTPases act as molecular switches and their activities are controlled by a large number of regulatory molecules that affect either GTP loading (guanine nucleotide exchange factors or GEFs) or GTP hydrolysis (GTPase activating proteins or GAPs). In their active state, they interact with a continually increasing, functionally complex array of downstream effectors.

• File Size: 10150 KB
• Print Length: 848 pages
• Publisher: Academic Press;
  
• Publication Date: February 21, 2006
• Sold by: Amazon Digital Services LLC
• Language: English
• ASIN: B0019498LS

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