This chapter discusses the proteolytic enzymes of the complement system and pathway of the activation of complement. The activation of complement system depends on the aggregation of the antibody molecules caused by their binding to the antigen. The major feature of the activation is the conversion of proteolytic zymogens to active proteinases that catalyze the conversion of other zymogens to active enzymes down the pathway. There are two pathways of activation, named the classical and the alternative pathway, both of which can be initiated by addition of antibody aggregates to serum. The alternative pathway can also be activated by the addition to serum of high-molecular-weight polysaccharides such as are found in bacterial or yeast cell walls. In addition, the chapter describes the serum proteins that control the activation of complement either by inhibition of proteolysis or by proteolytic digestion of the different components. Series: Methods in Enzymology (Book 80) Hardcover: 936 pages Publisher: Academic Press; 1 edition (March 14, 1982) Language: English ISBN-10: 0121819809 ISBN-13: 978-0121819804 Product Dimensions: 6 x 9 inches Link Download http://nitroflare.com/view/719360C075B03C2https://drive.google.com/drive/folders/1yLBzZ1rSQoNjmWeJTZ3WGQHg04L1
