Methods in Molecular Biology Vol.1335 G Protein-Coupled Receptors in Drug Discovery 2nd Edition

This detailed volume provides an overview of recent techniques employed in the field of G protein-coupled receptors (GPCRs) to screen for new drugs and to derive information about their receptor structure, dynamics, and function for the purpose of developing improved therapeutics. Owing to remarkable recent advances in the structural, biophysical, and biochemical analyses of these receptors, as well as a growing body of evidence hinting at the possible relevance of allosteric modulators, biased agonists, and oligomer-selective ligands as improved therapeutic agents, drug discovery for GPCRs has recently taken a completely new direction. For this book, expert contributors have shared their protocols and views on the impact of these methodologies on modern drug discovery. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

• Series: Methods in Molecular Biology (Book 1335)
• Hardcover: 327 pages
• Publisher: Humana Press; 2nd ed. 2015 edition (August 11, 2015)
• Language: English
• ISBN-10: 1493929135
• ISBN-13: 978-1493929139
• Product Dimensions: 10.4 x 7.2 x 0.9 inches

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